African Champions League 2016
2nd round / 1st leg
2015 Champions: TP Mazembe
| 106 | 19 Apr 2016 - 3 p.m. | |
 mamelodi-sundowns |
2 : 1 | AS Vita Club  |
| 107 | 19 Apr 2016 - 3 p.m. | |
 Entente Setif |
0 : 0 | Al Merreikh  |
| 108 | 19 Apr 2016 - 3 p.m. | |
| TP Mazembe |
1 : 1 | Wydad Casablanca  |
| 109 | 19 Apr 2016 - 3 p.m. | |
 Etoile du Sahel |
3 : 0 | Enyimba  |
| 110 | 19 Apr 2016 - 3 p.m. | |
 ZESCO United |
2 : 1 | Stade Malien  |
| 111 | 19 Apr 2016 - 3 p.m. | |
 Al Ahly SC |
2 : 1 | Young Africans  |
| 112 | 19 Apr 2016 - 3 p.m. | |
 Al Ahli Tripoli |
2 : 1 | ASEC Mimosas  |
| 113 | 19 Apr 2016 - 3 p.m. | |
| Mouloudia Béjaïa |
1 : 1 | Zamalek |